Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

摘要

► Lrp5−/− increased cancellous but not cortical bone loss with disuse. ► Lrp5−/− decreases load-induced new bone formation in males but not in females. ► Lrp5 G171V High Bone Mass mutation protected against bone loss with disuse but increased bone response to loading.